Enterotoxin tilimycin from gut-resident Klebsiella promotes mutational evolution and antibiotic resistance in mice
Authors: Kienesberger, S., Cosic, A., Kitsera, M., Raffl, S., Hiesinger, M., Leitner, E., Halwachs, B., Gorkiewicz, G., Glabonjat, R. A., Raber, G., Lembacher-Fadum, C., Breinbauer, R., Schild, S., & Zechner, E. L.
Journal: Nature Microbiology, 7, 1834-1848 (2022)
DOI: 10.1038/s41564-022-01260-3
Demonstrates that transient tilimycin synthesis in the murine gut acts as a pro-mutagenic antibiotic, accelerating de novo acquisition of antibiotic resistance in co-resident pathogens.