Microbiota-derived genotoxin tilimycin generates colonic stem cell mutations
Authors: Pöltl, L., Kitsera, M., Raffl, S., Schild, S., Cosic, A., Kienesberger, S., Unterhauser, K., Raber, G., Lembacher-Fadum, C., Breinbauer, R., Gorkiewicz, G., Sebastian, C., Hoefler, G., & Zechner, E. L.
Journal: Cell Reports, 42(3), 112199 (2023)
DOI: 10.1016/j.celrep.2023.112199
Shows that tilimycin accumulation leads to apoptotic erosion of intestinal epithelium and somatic colonic stem cell mutations.