Klebsiella oxytoca enterotoxins tilimycin and tilivalline have distinct host DNA-damaging and microtubule-stabilizing activities
Authors: Unterhauser, K., Pöltl, L., Schneditz, G., Kienesberger, S., Glabonjat, R. A., Kitsera, M., Pletz, J., Josa-Prado, F., Dornisch, E., Lembacher-Fadum, C., Roier, S., Gorkiewicz, G., Lucena, D., Barasoain, I., Kroutil, W., Wiedner, M., Loizou, J. I., Breinbauer, R., Díaz, J. F., Schild, S., Högenauer, C., & Zechner, E. L.
Journal: Proceedings of the National Academy of Sciences, 116(9), 3774-3783 (2019)
Foundational work establishing tilimycin as a DNA-alkylating genotoxin and tilivalline as a microtubule stabilizer, driving the pathogenesis of antibiotic-associated hemorrhagic colitis.